The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis.

ABSTRACT:

Background

Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining its advantages.

Methods

In this study, we investigated the effect of human fetal skin-derived stem cell (hFSSC) secretome in the treatment of liver fibrosis. To determine the therapeutic potential of the hFSSC secretome in liver fibrosis, we established the CCl₄-induced rat liver fibrosis model and administered hFSSC secretome in vivo. Moreover, we investigated the anti-fibrotic mechanism of hFSSC secretome in hepatic stellate cells (HSCs).

Results

Our results showed that hFSSC secretome effectively reduced co

SUBMITTER: Yao X 

PROVIDER: S-EPMC7650526 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature