Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P.

ABSTRACT:

Background

Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the expression of S100P in endometrial cancer and its precursor lesions, and to explore the possible mechanisms.

Methods

We collected paraffin sections of normal endometrium, simple and complex non-atypical hyperplasia, atypical hyperplasia, and endometrioid carcinoma. The expression of S100P in endometrial cancer and its precancerous lesions was observed using immunohistochemistry. We also cultured primary endometrial cells and endometrial cancer cell lines (Ishika

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7650527 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature