Genomic Instability Signature of Palindromic Non-Coding Somatic Mutations in Bladder Cancer.

ABSTRACT: Numerous pan-genomic studies identified alterations in protein-coding genes and signaling pathways involved in bladder carcinogenesis, while non-coding somatic alterations remain weakly explored. The goal of this study was to identify clinical biomarkers in non-coding regions for bladder cancer patients. We have previously identified in bladder tumors two non-coding mutational hotspots occurring at high frequencies (≥30%). These mutations are located close to the GPR126 and PLEKHS1 genes, at the guanine or the cytosine of a TGAACA core motif flanked, on both sides, by a stretch of palindromic sequences. Here, we hypothesize that such a pattern of recurrent non-coding mutations could be a signature of somatic genomic instability specifically involved in bladder cancer. We anal

SUBMITTER: Vacher S 

PROVIDER: S-EPMC7650671 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature