Inflammatory Breast Cancer: Clinical Implications of Genomic Alterations and Mutational Profiling.

ABSTRACT: Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer whose molecular basis is poorly understood. We performed a comprehensive molecular analysis of 24 IBC biopsies naïve of treatment, using a high-resolution microarray platform and targeted next-generation sequencing (105 cancer-related genes). The genes more frequently affected by gains were MYC (75%) and MDM4 (71%), while frequent losses encompassed TP53 (71%) and RB1 (58%). Increased MYC and MDM4 protein expression levels were detected in 18 cases. These genes have been related to IBC aggressiveness, and MDM4 is a potential therapeutic target in IBC. Functional enrichment analysis revealed genes associated with inflammatory regulation and immune response. High homologous recombinati

SUBMITTER: Faldoni FLC 

PROVIDER: S-EPMC7650681 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature