Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning.

ABSTRACT: In a short time, the COVID-19 pandemic has left the world with over 25 million cases and staggering death tolls that are still rising. Treatments for SARS-CoV-2 infection are desperately needed as there are currently no approved drug therapies. With limited knowledge of viral mechanisms, a network controllability method of prioritizing existing drugs for repurposing efforts is optimal for quickly moving through the drug approval pipeline using limited, available, virus-specific data. Based on network topology and controllability, 16 proteins involved in translation, cellular transport, cellular stress, and host immune response are predicted as regulators of the SARS-CoV-2 infected cell. Of the 16, eight are prioritized as possible drug targets where two, PVR and SCARB1, are previously unex

SUBMITTER: Ackerman EE 

PROVIDER: S-EPMC7650805 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature