Reliable quantification of ¹⁸F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio.

ABSTRACT:

Purpose

Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of microglia activation by PET with the translocator protein (TSPO) ligand ¹⁸F-GE-180. This study tested simplified methods for quantification of ¹⁸F-GE-180 PET.

Methods

Dynamic ¹⁸F-GE-180 PET with arterial blood sampling and metabolite correction was performed in five healthy volunteers and 20 liver-transplanted patients. Population-based input function templates were generated by averaging individual input functions normalized to the total area under the input function using a leave-one-out approach. Individual population-based input

SUBMITTER: Buchert R 

PROVIDER: S-EPMC7651670 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature