Association between vitamin D and uterine fibroids: a study protocol of an open-label, randomised controlled trial.

ABSTRACT:

Introduction

Uterine fibroids are the most common pelvic benign tumour with no satisfactory long-term medical treatment. Recent studies have demonstrated that vitamin D significantly inhibited the growth of fibroids in vitro, vivo and a small-sample clinical trial. Therefore, the aim of this randomised clinical trial (RCT) is to evaluate whether supplementation with vitamin D could reduce the risk and inhibit the growth of uterine fibroids in reproductive stage women.

Methods and analysis

The open-label, RCT comprises two parts, including parts I and II. In part I, 2230 vitamin D deficiency or vitamin D insufficiency patients without uterine fibroids will be randomly assigned to two groups: intervention group (according to the level of serum 25-hydroxyvitamin D₃,

SUBMITTER: Sheng B 

PROVIDER: S-EPMC7651728 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature