Plasma proteome in multiple sclerosis disease progression.

ABSTRACT:

Background

The pathophysiology of multiple sclerosis disease progression remains undetermined. The aim of this study was to identify differences in plasma proteome during different stages of MS disease progression.

Methods

We used a multiplex aptamer proteomics platform (Somalogic) for sensitive detection of 1129 proteins in plasma. MS patients were selected and categorized based on baseline and a 4-year follow-up EDSS (delta EDSS) scores; relapse-onset (RO) slow progression (n = 31), RO with rapid progression (n = 29), primary progressive (n = 30), and healthy controls (n = 20). The relation of baseline plasma protein levels with delta EDSS and different MRI progression parameters were assessed using linear regression models.

Results

Regression analyses of plasma pro

SUBMITTER: Malekzadeh A 

PROVIDER: S-EPMC7651845 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature