Targeting Ligands Deliver Model Drug Cargo into the Central Nervous System along Autonomic Neurons.

ABSTRACT: While biologic drugs such as proteins, peptides, or nucleic acids have shown promise in the treatment of neurodegenerative diseases, the blood-brain barrier (BBB) severely limits drug delivery to the central nervous system (CNS) after systemic administration. Consequently, drug delivery challenges preclude biological drug candidates from the clinical armamentarium. In order to target drug delivery and uptake into to the CNS, we used an in vivo phage display screen to identify peptides able to target drug-uptake by the vast array of neurons of the autonomic nervous system (ANS). Using next-generation sequencing, we identified 21 candidate targeted ANS-to-CNS uptake ligands (TACL) that enriched bacteriophage accumulation and delivered protein-cargo into the CNS after intraperitoneal (

SUBMITTER: Sellers DL 

PROVIDER: S-EPMC7651855 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature