The landscape of genetic susceptibility correlations among diseases and traits.

ABSTRACT:

Objective

The aim of the study was to comprehensively explore the genetic susceptibility correlations among diseases and traits from large-scale individual genotype data.

Materials and methods

Based on a knowledge base of genetic variants significantly (P < 5 × 10 -8 ) linked with human phenotypes, genetic risk scores (GRSs) of diseases or traits were calculated for 2504 individuals with whole-genome sequencing data from the 1000 Genomes Project. Associations between diseases/traits were statistically evaluated by pairwise correlation analysis of GRSs. Overlaps between the genetic susceptibility correlations and disease comorbidity associations from hospital claims data in more than 30 million patients in United States were assessed.

Results

Correlation analysis of GR

SUBMITTER: Ohn JH 

PROVIDER: S-EPMC7651975 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature