Lifetime cancer prevalence and life history traits in mammals.

ABSTRACT:

Background

Cancer is a common diagnosis in many mammalian species, yet they vary in their vulnerability to cancer. The factors driving this variation are unknown, but life history theory offers potential explanations to why cancer defense mechanisms are not equal across species.

Methodology

Here we report the prevalence of neoplasia and malignancy in 37 mammalian species, representing 11 mammalian orders, using 42 years of well curated necropsy data from the San Diego Zoo and San Diego Zoo Safari Park. We collected data on life history components of these species and tested for associations between life history traits and both neoplasia and malignancy, while controlling for phylogenetic history.

Results

These results support Peto's paradox, in that we find no associat

SUBMITTER: Boddy AM 

PROVIDER: S-EPMC7652303 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature