SARS-CoV-2 and interferon blockade.

ABSTRACT: The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

SUBMITTER: Diamond B 

PROVIDER: S-EPMC7652589 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature