Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore.

ABSTRACT:

Background

The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about the characteristics of transmission networks of people who inject drugs (PWID).

Methods

Sequencing of a segment of the HCV genome was performed on samples collected from a community-based cohort of PWID between August 2005 and December 2016. Phylogenetic trees were inferred, and clusters were identified (70% bootstrap threshold; 0.04 maximum genetic distance threshold). We describe sex, race, age difference, and HIV infection status of potential transmission partners. Logistic regression was used to assess factors associated with being in an HCV cluster.

Res

SUBMITTER: Falade-Nwulia O 

PROVIDER: S-EPMC7652590 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature