Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure.

ABSTRACT:

Background/aims

Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established a model of arrhythmia-induced heart failure (HF) in zebrafish and investigated the role of renin-angiotensin-aldosterone system (RAAS) modulation by using an angiotensin II type 1 receptor blocker, fimasartan, through the assessment of cellular and physiologic responses, morbidity, and mortality.

Methods

HF was induced in zebrafish larvae by exposure to 20 μM terfenadine. Morphologic, physiologic, and functional parameters were assessed in the presence or absence of fimasartan treatment.

Results

Zebrafish exposed to terfenadine showed marked dilatation of the ventricle and reduced

SUBMITTER: Quan H 

PROVIDER: S-EPMC7652659 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature