In silico analysis of epitope-based CadF vaccine design against Campylobacter jejuni.

ABSTRACT:

Objective

Vaccination is an important strategy for the eradication of infectious diseases. CadF protein of Campylobacter jejuni is one of the important factors in the pathogenesis of this bacterium. The purpose of this work was to perform a bioinformatics study to identify an epitope-based CadF vaccine, as a subunit vaccine. Full protein sequences of CadF were extracted from the NCBI and UniProt databases and subjected to in silico evaluations, including sequence analysis, allergenicity, antigenicity, epitope conservancy, and molecular docking assessments done by different servers.

Results

The results showed that CadF was a highly conserved protein belonging to the outer member proteins superfamily. Among the evaluated epitopes, LSDSLALRL was identified as an antigenic and n

SUBMITTER: Moballegh Naseri M 

PROVIDER: S-EPMC7652678 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature