Grey and white matter volumes in early childhood: A comparison of voxel-based morphometry pipelines.

ABSTRACT: Early childhood is an important period of sensory, motor, cognitive and socio-emotional maturation, yet relatively little is known about the brain changes specific to this period. Voxel-based morphometry (VBM) is a technique to estimate regional brain volumes from magnetic resonance (MR) images. The default VBM processing pipeline can be customized to increase accuracy of segmentation and normalization, yet the impact of customizations on analyses in young children are not clear. Here, we assessed the impact of different preprocessing steps on T1-weighted MR images from typically developing children in two separate cohorts. Data were processed with the Computational Anatomy Toolbox (CAT12), using seven different VBM pipelines with distinct combinations of tissue probability maps (TPMs) and

SUBMITTER: Haynes L 

PROVIDER: S-EPMC7652784 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature