Ontology highlight
ABSTRACT:
SUBMITTER: Zaslavsky AB
PROVIDER: S-EPMC7652857 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20201109 1
Strategies that interfere with the binding of the receptor programmed cell death protein-1 (PD-1) to programmed death ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those that are negative for PD-L1. Precisely why patients with PD-L1 negative tumors respond to PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show that platelet-derived PD-L1 regulates the growth of PD-L1 negative tumors and that interference with platelet binding to PD-L1 negative c ...[more]