Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA.

ABSTRACT: The carbon storage regulator (Csr) or repressor of stationary phase metabolites (Rsm) system of Gammaproteobacteria is among the most complex and best-studied posttranscriptional regulatory systems. Based on a small RNA-binding protein, CsrA and homologs, it controls metabolism, physiology, and bacterial lifestyle decisions by regulating gene expression on a vast scale. Binding of CsrA to sequences containing conserved GGA motifs in mRNAs can regulate translation, RNA stability, riboswitch function, and transcript elongation. CsrA governs the expression of dozens of transcription factors and other regulators, further expanding its influence on cellular physiology, and these factors can participate in feedback to the Csr system. Expression of csrA itself is subject to autoregu

SUBMITTER: Pourciau C 

PROVIDER: S-EPMC7652899 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature