Impact of inter-reader contouring variability on textural radiomics of colorectal liver metastases.

ABSTRACT:

Background

Radiomics is expected to improve the management of metastatic colorectal cancer (CRC). We aimed at evaluating the impact of liver lesion contouring as a source of variability on radiomic features (RFs).

Methods

After Ethics Committee approval, 70 liver metastases in 17 CRC patients were segmented on contrast-enhanced computed tomography scans by two residents and checked by experienced radiologists. RFs from grey level co-occurrence and run length matrices were extracted from three-dimensional (3D) regions of interest (ROIs) and the largest two-dimensional (2D) ROIs. Inter-reader variability was evaluated with Dice coefficient and Hausdorff distance, whilst its impact on RFs was assessed using mean relative change (MRC) and intraclass correlation coefficient (ICC)

SUBMITTER: Rizzetto F 

PROVIDER: S-EPMC7652946 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature