Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.

ABSTRACT: Cocaine addiction develops as a continuum from recreational to habitual and ultimately compulsive drug use. Cocaine addicts show reduced brain activity. However, it is not clear if this condition results from individual predisposing traits or is the result of chronic cocaine intake. A translational neuroimaging approach with an animal model distinguishing non-addict-like vs. addict-like animals may help overcome the limitations of clinical research by comparing controlled experimental conditions that are impossible to obtain in humans. Here we aimed to evaluate neuronal activity in freely moving rats by manganese enhanced magnetic resonance imaging in the 0/3crit model of cocaine addiction. We show that addict-like rats exhibit reduced neuronal activity compared to cocaine-naïve controls d

SUBMITTER: Cannella N 

PROVIDER: S-EPMC7653042 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature