TACI Constrains T_H17 Pathogenicity and Protects against Gut Inflammation.

ABSTRACT: TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) plays critical roles in B cells by promoting immunoglobulin class switching and plasma cell survival. However, its expression and function in T cells remain controversial. We show here that TACI expression can be strongly induced in murine CD4⁺ T cells in vitro by cytokines responsible for T_H17 but not T_H1 or T_H2 differentiation. Frequencies and numbers of T_H17 cells were elevated in TACI^{-/ -} compared with wild-type mice as well as among TACI^{-/ -} versus wild-type CD4⁺ T cells in mixed bone marrow chimeras, arguing for a T cell-intrinsic effect in the contribution of TACI deficiency to T

SUBMITTER: Tan AH 

PROVIDER: S-EPMC7653077 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature