Enterovirus genomic load and disease severity among children hospitalised with hand, foot and mouth disease.

ABSTRACT:

Background

Examining associations between viral genomic loads of enteroviruses and clinical severity is important for promoting and improving development of antiviral drugs related to hand, foot and mouth disease (HFMD).

Methods

Throat swabs were collected from HFMD cases at acute phase of illness using a standardized technique in a prospective study. The viral genomic load was categorized into low, medium, and high groups using parameters of real-time reverse transcription-polymerase chain reaction. The clinical severities were assessed with four indicators, respectively.

Findings

We analysed 1109 HFMD cases, including 538 children with CV-A6, 231 with CV-A16, 156 with EV-A71, 78 with CV-A10, 59 with CV-A4, and 47 with CV-A2. EV-A71 genomic load categories were assoc

SUBMITTER: Song C 

PROVIDER: S-EPMC7653080 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature