Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine.

ABSTRACT: Immunotherapy has become a cornerstone in the treatment of cancer and changed the way clinicians and researchers approach tumor vulnerabilities. Durable responses are commonly observed with immune checkpoint inhibitors in highly immunogenic tumors, while the infusion of T cells genetically engineered to express chimeric antigen receptors (CARs) has shown impressive efficacy in certain types of blood cancer. Nevertheless, harnessing our own immunity has not proved successful for most breast cancer patients. In the era of genomic medicine, cellular immunotherapies may provide a more personalized and dynamic tool against tumors displaying heterogeneous mutational landscapes and antigenic pools. This approach encompasses multiple strategies including the adoptive transfer of tumor-infiltrating

SUBMITTER: Fuentes-Antras J 

PROVIDER: S-EPMC7653090 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature