KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

ABSTRACT:

Background

Kirsten rat sarcoma vial oncogene (KRAS) is one of the most prevalent oncogenes in multiple cancer types, but the incidence is different between the Asian and non-Asian populations. The recent development of KRAS G12C targeting drug has shown great promise. It is thus important to understand the genomic landscape of KRAS G12C in a specific population.

Methods

Sequencing data of 11,951 tumor samples collected from 11/2016 to 7/2019 from multiple centres in China were analyzed for KRAS mutation status. Concomitant genomic aberrations were further analyzed in tumors with KRAS G12C mutations, which were sequenced with comprehensive cancer panel including over 450 cancer-related genes. Smoking status and its correlation with KRAS</

SUBMITTER: Loong HH 

PROVIDER: S-EPMC7653137 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature