Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib.

ABSTRACT:

Background

T790M relative allele frequency (RAF) in plasma, calculated by the ratio of T790M to epidermal growth factor receptor (EGFR)-sensitizing mutation allele frequencies (AF), is associated with osimertinib response in patients with progressive non-small cell lung cancer (NSCLC) post 1^st generation EGFR-tyrosine kinase inhibitor (TKI) treatment. However, which subgroup of patients carry concurrent resistance mechanisms and have poor responsiveness to osimertinib remains unknown.

Methods

Matched re-biopsy tissue and plasma samples obtained from 32 patients who had progression following 1^st generation EGFR-TKI treatment were genotyped using next-generation sequencing (NGS) to investigate which subgroup of patients, classified by plasma position 790

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7653156 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature