Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity.

ABSTRACT:

Objectives

Silicate bioactive glass (BG) has been widely demonstrated to stimulate both of the hard and soft tissue regeneration, in which ion products released from BG play important roles. However, the mechanism by which ion products act on cells on cells is unclear.

Materials and methods

Human umbilical vein endothelial cells and human bone marrow stromal cells were used in this study. Fluorescence recovery after photobleaching and generalized polarization was used to characterize changes in cell membrane fluidity. Migration, differentiation and apoptosis experiments were carried out. RNA and protein chip were detected. The signal cascade is simulated to evaluate the effect of increased cell membrane fluidity on signal transduction.

Results

We have demonstrated tha

SUBMITTER: Yan L 

PROVIDER: S-EPMC7653244 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature