N⁶ -methyladenosine (m⁶A) RNA modification in human cancer.

ABSTRACT: N⁶ -methyladenosine (m⁶ A) RNA modification, first discovered in 1974, is the most prevalent, abundant and penetrating messenger RNA (mRNA) modification in eukaryotes. This governs the fate of modified transcripts, regulates RNA metabolism and biological processes, and participates in pathogenesis of numerous human diseases, especially in cancer through the reciprocal regulation of m⁶ A methyltransferases ("writers") and demethylases ("erasers") and the binding proteins decoding m⁶ A methylation ("readers"). Accumulating evidence indicates a complicated regulation network of m⁶ A modification involving multiple m⁶ A-associated regulatory proteins whose biological functions have been further analysed. This review aimed to sum

SUBMITTER: Huo FC 

PROVIDER: S-EPMC7653258 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature