PRKAR2B-HIF-1α loop promotes aerobic glycolysis and tumour growth in prostate cancer.

ABSTRACT:

Objectives

Reprogramming of cellular metabolism is profoundly implicated in tumorigenesis and can be exploited to cancer treatment. Cancer cells are known for their propensity to use glucose-dependent glycolytic pathway instead of mitochondrial oxidative phosphorylation for energy generation even in the presence of oxygen, a phenomenon known as Warburg effect. The type II beta regulatory subunit of protein kinase A (PKA), PRKAR2B, is highly expressed in castration-resistant prostate cancer (CRPC) and contributes to tumour growth and metastasis. However, whether PRKAR2B regulates glucose metabolism in prostate cancer remains largely unknown.

Materials and methods

Loss-of-function and gain-of-function studies were used to investigate the regulatory role of PRKAR2B in aerobic g

SUBMITTER: Xia L 

PROVIDER: S-EPMC7653268 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature