PGE₂ upregulates gene expression of dual oxidase in a lepidopteran insect midgut via cAMP signalling pathway.

ABSTRACT: In insect midgut, prostaglandins (PGs) play a crucial role in defending bacterial and malarial pathogens. However, little is known about the PG signalling pathway in the midgut. A dual oxidase (Se-Duox) with presumed function of catalysing reactive oxygen species (ROS) production in the midgut was identified in beet armyworm, Spodoptera exigua. Se-Duox was expressed in all developmental stages, exhibiting relatively high expression levels in the midgut of late larval instars. Se-Duox expression was upregulated upon bacterial challenge. RNA interference (RNAi) of Se-Duox expression significantly suppressed ROS levels in the midgut lumen. The suppression of ROS levels increased insecticidal activity of Serratia marcescens after oral infection. Intere

SUBMITTER: Sajjadian SM 

PROVIDER: S-EPMC7653354 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature