Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases.

ABSTRACT:

Background

In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and investigated whether they could be used as biomarkers in these diseases.

Methods

In the discovery cohort, the gene expression level of 84 lncRNAs were measured in the blood of 24 adult patients including healthy controls and patients with asthma and COPD. In the replication cohort the expression of 6 selected lncRNAs were measured in 163 subjects including healthy controls and adults with allergic rhinitis, asthma, COPD and children with asthma. It was evaluated whether these lncRNAs can be used as diagnostic biomarkers for any studied disease. With systems biol

SUBMITTER: Gal Z 

PROVIDER: S-EPMC7653503 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature