Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors.

ABSTRACT: Inorganic arsenic is known to be a human carcinogen. Previous studies have reported that DNA methylation changes are involved in arsenic-induced carcinogenesis, therefore, DNA methylation changes that are specific to arsenic-induced tumors would be useful to distinguish tumors induced by arsenic from tumors caused by other factors and to dissect arsenic carcinogenesis. Previous studies have shown that gestational arsenic exposure of C3H mice, which tend to spontaneously develop liver tumors, increases the incidence of tumors in male offspring. In this study we used the same experimental protocol as in those previous studies and searched for DNA regions where methylation status was specifically altered in the liver tumors of arsenic-exposed offspring by using methylated DNA immunoprecipitat

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC7653529 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature