Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

ABSTRACT:

Importance

Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed.

Objective

To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19.

Design, setting, and participants

This was a multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US. Adults hospitalized with respiratory symptoms from severe acute respiratory syndrome coronavirus 2 infection were enrolled between April 2 and June 19, 2020, with the last outcome assessment on July 17, 2020. The planned sample size was 510 patients, with interim analyses planned after every 102 patients were enrolled. The trial was stopped at the fourth interim analysis for futility with a samp

SUBMITTER: Self WH 

PROVIDER: S-EPMC7653542 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature