Aberrant expression of miR-16, B12 and CD272 in peripheral blood mononuclear cells from patients with active tuberculosis.

ABSTRACT: Tuberculosis (TB) immunity is affected by complex immune regulation processes, which involve various immune cells, immune molecules, and cytokines. Here, we evaluated the expression of B12, CD272 and miR-16 in peripheral blood mononuclear cells (PBMC) of patients with active pulmonary tuberculosis. The results showed that monocytes expressing CD272 or B12 were down-regulated in patients with tuberculosis. The expression of B12 and CD272 in T cells and monocytes is related to tuberculosis. In TB patients, the up-regulation of miR-16 was negatively correlated with B12 mRNA expression, miR-16 was mainly expressed in CD14⁺ monocytes, and CD272 mRNA was mainly expressed in CD19⁺ B cells. It is worth noting that the overexpression of miR-16 inhibits the expression of CD272

SUBMITTER: Lin D 

PROVIDER: S-EPMC7653578 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature