Characterization and Functional Assessment of Endothelial Progenitor Cells in Ischemic Stroke Patients.

ABSTRACT: Endothelial dysfunction has been implicated in atherosclerosis, ischemic heart disease, and stroke. Endothelial progenitor cells (EPCs), found in the bone marrow and peripheral blood as rare cell population, demonstrated a high proliferation and differentiation capacity. Understanding how such diseases influence the quantity and functionality of EPCs is essential for the development of novel therapies. This study aims to investigate the factors that affect the quantity and functionality of circulating EPCs in stroke patients and healthy controls. Blood samples were collected once from healthy donors (n = 30) and up to 3 times (within 7 days (baseline), 3 and 12 months post-stroke) from stroke patients (n = 207). EPC subpopulations were isolated with flow cytometry for characterization. The

SUBMITTER: Kukumberg M 

PROVIDER: S-EPMC7653671 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature