Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging.

ABSTRACT: Stroke leads to long term sensory, motor and cognitive impairments. Most patients experience some degree of spontaneous recovery which is mostly incomplete and varying greatly among individuals. The variation in recovery outcomes has been attributed to numerous factors including lesion size, corticospinal tract integrity, age, gender and race. It is well accepted that genetics play a crucial role in stroke incidence and accumulating evidence suggests that it is also a significant determinant in recovery. Among the number of genes and variations implicated in stroke recovery the val66met single nucleotide polymorphism (SNP) in the BDNF gene influences post-stroke plasticity in the most significant ways. Val66met is the most well characterized BDNF SNP and is common (40-50 % in Asian and 25-

SUBMITTER: Balkaya M 

PROVIDER: S-EPMC7653673 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature