Ontology highlight
ABSTRACT:
SUBMITTER: Kinney BA
PROVIDER: S-EPMC7653682 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kinney Brian A BA Al Anber Arwa A Row Richard H RH Tseng Yu-Jung YJ Weidmann Maxwell D MD Knaut Holger H Martin Benjamin L BL
Cell reports 20201001 4
Animal embryogenesis requires a precise coordination between morphogenesis and cell fate specification. During mesoderm induction, mesodermal fate acquisition is tightly coordinated with the morphogenetic process of epithelial-to-mesenchymal transition (EMT). In zebrafish, cells exist transiently in a partial EMT state during mesoderm induction. Here, we show that cells expressing the transcription factor Sox2 are held in the partial EMT state, stopping them from completing the EMT and joining t ...[more]