Longitudinal profiling of the gut microbiome in patients with psoriatic arthritis and ankylosing spondylitis: a multicentre, prospective, observational study.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory disease of the skin affecting 2-3% of UK population. 30% of people affected by psoriasis will develop a distinct form of arthritis within 10 years of the skin condition onset. Although the pathogenesis of psoriatic arthritis is still unknown, there is a genetic predisposition triggered by environmental factors. Limited but convincing evidence link the gut microbiome to psoriatic arthritis. The Microbiome in Psoriatic ARThritis (Mi-PART) study propose is to characterise the microbiome-metabolic interface in patients affected by psoriatic arthritis to deepen our understanding of the pathogenesis of the disease.

Methods

This is a multicentre, prospective, observational study. Psoriatic arthritis (n = 65) and ankylosing spondylitis

SUBMITTER: Miguens Blanco J 

PROVIDER: S-EPMC7653819 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature