Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles.

ABSTRACT:

Background

The association of molecular phenotypes, such as gene transcript levels, with human common genetic variation can help to improve our understanding of interindividual variability of tissue-specific gene regulation and its implications for disease.

Methods

With the aim to capture the spectrum of biological processes affected by regulatory common genetic variants (minor allele frequency ≥ 1%) in healthy hair follicles (HFs) from scalp tissue, we performed a genome-wide mapping of cis-acting expression quantitative trait loci (eQTLs) in plucked HFs, and applied these eQTLs to help further explain genomic findings for hair-related traits.

Results

We report 374 high-confidence eQTLs found in occipital scalp tissue, whose associated genes (eGenes) showed enrichmen

SUBMITTER: Herrera-Rivero M 

PROVIDER: S-EPMC7653834 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature