A Randomized Controlled Trial of Ovarian Suppression in Premenopausal Women: No Change in Free-Living Energy Expenditure.

ABSTRACT:

Objective

The purpose of this study was to determine whether suppression of ovarian function (gonadotropin-releasing hormone agonist [GnRH_AG ]) for 24 weeks in premenopausal women approaching menopause causes changes in body composition and a decline in free-living physical activity energy expenditure (PAEE) and whether endurance exercise training attenuates the changes.

Methods

Premenopausal women who were approaching menopause (mean [SD]: age 46 [3] years, BMI 26.3 [4.8] kg/m² ) were randomized to 24 weeks of GnRH_AG (n = 14), GnRH_AG + Exercise (n = 11), or placebo (n = 9). Endurance exercise was performed 4 days per week with the goal of expending 200 to 300 kcal per session. Primary outcome measurements included body compositio

SUBMITTER: Gavin KM 

PROVIDER: S-EPMC7653843 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature