Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort.

ABSTRACT:

Background

Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthritis phase of clinically suspect arthralgia (CSA) expression of immune genes differ between patients who do or do not develop clinically evident inflammatory arthritis (IA).

Methods

Two hundred thirty-six consecutive patients presenting with arthralgia clinically suspected for progression to RA were followed until IA development or else for median 24 months (IQR 12-26). Baseline whole blood RNA expression was determined for a previously identified set of 133 genes associated with the innate and adaptive immune system by dual-color reverse-transcription multiple

SUBMITTER: Niemantsverdriet E 

PROVIDER: S-EPMC7653888 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature