The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.

ABSTRACT:

Background

Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of outcome and the impact on ET decision.

Methods

In total, 643 pure DCIS, diagnosed at Nottingham University Hospitals, were assessed for ER. Clinicopathological data were correlated against ER status, together with assessment of recurrence rate.

Results

ER positivity was observed in 74% (475/643) of cases. ER positivity was associated with clinicopathological variables of good prognosis; however, outcome analysis revealed that ER status was not associated with local recurrence. In the intermediate- and high-grade ER-positive DC

SUBMITTER: Miligy IM 

PROVIDER: S-EPMC7653904 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature