Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions.

ABSTRACT:

Background

Molecular Recognition Features (MoRFs) are short protein regions present in intrinsically disordered protein (IDPs) sequences. MoRFs interact with structured partner protein and upon interaction, they undergo a disorder-to-order transition to perform various biological functions. Analyses of MoRFs are important towards understanding their function.

Results

Performance is reported using the MoRF dataset that has been previously used to compare the other existing MoRF predictors. The performance obtained in this study is equivalent to the benchmarked OPAL predictor, i.e., OPAL achieved AUC of 0.815, whereas the model in this study achieved AUC of 0.819 using TEST set.

Conclusion

Achieving comparable performance, the proposed method can be used as an alternati

SUBMITTER: Sharma R 

PROVIDER: S-EPMC7653905 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature