Galectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma.

ABSTRACT:

Background

High probability of metastasis limited the long-term survival of patients with hepatocellular carcinoma (HCC). Our previous study revealed that Galectin-3 was closely associated with poor prognosis in HCC patients.

Methods

The effects of Galectin-3 on tumour metastasis were investigated in vitro and in vivo, and the underlying biological and molecular mechanisms involved in this process were evaluated.

Results

Galectin-3 showed a close correlation with vascular invasion and poor survival in a large-scale study in HCC patients from multiple sets. Galectin-3 was significantly involved in diverse metastasis-related processes in HCC cells, such as angiogenesis and epithelial-to-mesenchymal transition (EMT). Mechanistically, Galectin-3 activated the PI3K-Akt-GSK

SUBMITTER: Song M 

PROVIDER: S-EPMC7653936 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature