Shortwave infrared emitting multicolored nanoprobes for biomarker-specific cancer imaging in vivo.

ABSTRACT:

Background

The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we engineered an imaging platform capable of targeting different tumor biomarkers using a multi-colored library of nanoprobes. These probes contain rare-earth elements that emit light in the short-wave infrared (SWIR) wavelength region (900-1700 nm), which exhibits reduced absorption and scattering compared to visible and NIR, and are rendered biocompatible by encapsulation in human serum albumin. The spectrally distinct emissions of the holmium (Ho), erbium (Er), and thulium (Tm) cations that constitute the cores of these nanoprobes make them attractive candidates for optica

SUBMITTER: Kantamneni H 

PROVIDER: S-EPMC7654009 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature