Mendelian randomization study of inflammatory bowel disease and bone mineral density.

ABSTRACT:

Background

Recently, the association between inflammatory bowel disease (including ulcerative colitis and Crohn's disease) and BMD has attracted great interest in the research community. However, the results of the published epidemiological observational studies on the relationship between inflammatory bowel disease and BMD are still inconclusive. Here, we performed a two-sample Mendelian randomization analysis to investigate the causal link between inflammatory bowel disease and level of BMD using publically available GWAS summary statistics.

Methods

A series of quality control steps were taken in our analysis to select eligible instrumental SNPs which were strongly associated with exposure. To make the conclusions more robust and reliable, we utilized several robust analyt

SUBMITTER: Wu F 

PROVIDER: S-EPMC7654011 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature