Memory-assisted reinforcement learning for diverse molecular de novo design.

ABSTRACT: In de novo molecular design, recurrent neural networks (RNN) have been shown to be effective methods for sampling and generating novel chemical structures. Using a technique called reinforcement learning (RL), an RNN can be tuned to target a particular section of chemical space with optimized desirable properties using a scoring function. However, ligands generated by current RL methods so far tend to have relatively low diversity, and sometimes even result in duplicate structures when optimizing towards desired properties. Here, we propose a new method to address the low diversity issue in RL for molecular design. Memory-assisted RL is an extension of the known RL, with the introduction of a so-called memory unit. As proof of concept, we applied our method to generate structures with a de

SUBMITTER: Blaschke T 

PROVIDER: S-EPMC7654024 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature