Molecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal.

ABSTRACT:

Background

Molecular epidemiology can provide important information regarding the genetic diversity and transmission of Plasmodium falciparum, which can assist in designing and monitoring elimination efforts. However, malaria molecular epidemiology including understanding the genetic diversity of the parasite and performing molecular surveillance of transmission has been poorly documented in Senegal. Next Generation Sequencing (NGS) offers a practical, fast and high-throughput approach to understand malaria population genetics. This study aims to unravel the population structure of P. falciparum and to estimate the allelic diversity, multiplicity of infection (MOI), and evolutionary patterns of the malaria parasite using the NGS platform.

Methods

Multiplex amplicon deep sequ

SUBMITTER: Ndiaye T 

PROVIDER: S-EPMC7654156 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature