SLy2-deficiency promotes B-1 cell immunity and triggers enhanced production of IgM and IgG₂ antibodies against pneumococcal vaccine.

ABSTRACT:

Background

Despite the benefits of existing vaccines, Streptococcus pneumoniae is still responsible for the greatest proportion of respiratory tract infections around the globe, thereby substantially contributing to morbidity and mortality in humans. B-1 cells are key players of bacterial clearance during pneumococcal infection and even provide long-lasting immunity towards S. pneumoniae. Previous reports strongly suggest an essential role of the immunoinhibitory adapter Src homology domain 3 lymphocyte protein 2 (SLy2) for B-1 cell-mediated antibody production. The objective of this study is to evaluate S. pneumoniae-directed B cell responses in the context of SLy2 deficiency.

Methods

B-1 cell populations were analyzed via flow cytometry before and after pneumococcal immuni

SUBMITTER: Jaufmann J 

PROVIDER: S-EPMC7654406 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature