Self-Folding 3D Silk Biomaterial Rolls to Facilitate Axon and Bone Regeneration.

ABSTRACT: Biomaterial scaffold designs are needed for self-organizing features related to tissue formation while also simplifying the fabrication processes involved. Toward this goal, silk protein-based self-folding scaffolds to support 3D cell culture, while providing directional guidance and promotion of cell growth and differentiation, are reported. A simple and robust one-step self-folding approach is developed using bilayers consisting of a hydrogel and silk film in aqueous solution. The 3D silk rolls, with patterns transferred from the initially prepared 2D films, guide the directional outgrowth of neurites and also promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs). The osteogenic outcomes are further supported by enhanced biomechanical performance. By utilizing th

SUBMITTER: Huang Y 

PROVIDER: S-EPMC7654509 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature