Stimulus intensity-dependent recruitment of Na_V1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus.

ABSTRACT: We investigated voltage-gated sodium channel (Na_V1) subunits that regulate action potential initiation in the nerve terminals of vagal nodose C-fibers innervating the esophagus. Extracellular single fiber recordings were made from the nodose C-fibers, with mechanically sensitive nerve terminals in the isolated innervated guinea pig esophagus. Na_V1 inhibitors were selectively delivered to the tissue-containing nerve terminals. Graded esophageal distention was used for mechanical stimulation. The Na_V1.7 inhibitor PF-05089771 nearly abolished action potential initiation in response to low levels of esophageal distention but only partially inhibited the response to higher levels of esophageal distention. The PF-05089771-insensitive component of the response pro

SUBMITTER: Ru F 

PROVIDER: S-EPMC7654645 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature